A higher-performance version of the base Mark 3 model was offered under the Mark 3D designation, which was fitted with a different head that used the desmodromic system derived from the Ducati 350 SCD racers.
In addition to the desmodromic system, the lightweight hairspring valves were retained, while the rest of the engine was identical to the one used on the basic Mark 3 model, as well as most cycle parts.
In 1971, the base Mark 3 and Mark 3D versions diverged. The desmodromic model was renamed 450 Desmo and featured a cafe racer styling. It was fitted with features like a clip-on handlebar, a fiberglass fuel tank, and a monoposto single seat.
In 1973, the bike was restyled by Leopoldo Tartarini, gaining a metal fuel tank, different side panels, Smiths instruments, a one-piece dual seat, and a rear mudguard. The bike was finished in the same yellow and black colors as the 750S model.
In 1974, the Italian motorcycle manufacturer launched the Ducati 450 Desmo, a cafe racer-styled motorcycle in its last year of production. The bike received a few improvements for the last time, such as a Ceriani front fork alongside a single 280 mm Brembo disc.
As for the power figures, the 1974 Ducati 450 Desmo had installed a 436cc four-stroke air-cooled single-cylinder engine with a Dell'Orto carburetor in charge, boasting 27 hp with a peak force at 6,700 rpm.